Cleveland Clinic has unveiled its 10th annual listing of the 10 most powerful medical innovations for 2016.

The top innovations range from faster methods of creating vaccines to a process for rewriting genetic code. A panel of 75 Cleveland Clinic physicians and scientists select the breakthrough drug therapies, medical devices and public health initiatives.

Here, in order of anticipated importance, are the Top 10 Medical Innovations for 2016:

1. Rapid Development of Epidemic-Battling Vaccines

Researchers are developing effective vaccines faster than ever to prevent epidemics. It’s an effort given new urgency by the 2014 Ebola epidemic in Africa and of U.S. bacterial meningococcal outbreaks.

“The rapid scientific response to recent epidemics indicates that we’ve achieved a new level of sophistication in the area of vaccine development,” says Steven Gordon, MD, chair of the Department of Infectious Disease at Cleveland Clinic. “It was a global effort involving thousands of people, aided by information technology and instant communication.”

The most promising Ebola vaccine emerged in only 12 months. While not yet licensed for use in humans, it’s expected to be available in 2016.

2. Genomics-based Clinical Trials

Genetic profiling offers new hope to people suffering fatal diseases, like cancer. By upending a 50-year-old research model, genomic-based tests may increase the speed and flexibility of clinical trials and guide desperate patients to the most promising experimental treatments.

“Patients are waiting too long to enter clinical trials for drugs that may or may not be effective for their specific variation of cancer,” says Charis Eng, MD, PhD, chair of the Cleveland Clinic Genomic Institute. “End-stage cancer patients especially may not have that time.”

3. Gene Editing Using CRISPR

A new, inexpensive technique called CRISPR, is allowing gene editing to be adopted in labs everywhere.

CRISPR, which stands for “clustered regularly interspaced short palindromic repeats,” is being touted as a way to eliminate genetic diseases. It can identify and remove bad genes from a DNA strand for as little as $30.

4. Water Purification System for Prevention of Infectious Disease

An estimated 700 million people worldwide are drinking unsafe water daily, according to the World Health Organization. A new kind of waste treatment plant may offer an affordable solution. It has shown promise converting human waste into clean drinking water while also generating electricity to run the machine.

The sewage processor costs about $1.5 million and is able to handle the waste of 100,000 people daily. It is now being tested in Dakar, Senegal.

5. Cell-free Fetal DNA Testing

The desire to deliver healthy babies has created a $2 billion pregnancy wellness market but doesn't really address concerns about genetic diseases. Studies show that Cell-free Fetal DNA Testing more accurately predicts Down's and Edwards’s syndromes than standard blood tests and ultrasounds. 

6. Cancer Screening via Protein Biomarker Analysis

In 2016, a new biomarker platform is hitting the market that should offer more accurate cancer screenings and more chances of early detection.

Protein biomarker analysis focuses on changes in the structure of certain proteins circulating in the blood. In contrast to examining genetic mutations, which can indicate the risk of cancer, the new tests give real-time information on cancer’s presence.

7. Naturally Controlled Artificial Limbs

In recent years, researchers have discovered that neural signals associated with limb movement can be de-coded by computers, leading to computer-controlled artificial limbs.

More recently, they have demonstrated that sensors implanted in the brain can control prosthetic arms, wheelchairs and even a full-body exoskeleton. Now researchers are working on making “brain-machine interfaces,” BMIs, safer and cheaper with lower-cost robotic components.

8. First Treatment for HSDD

In 2015, the FDA approved flibanserin, the first medication designed to treat female hypoactive sexual desire disorder (HSDD), or loss of sexual desire in premenopausal women.

“This innovative medication is well-studied and it does help restore sexual desire in women who have HSDD,” says Holly L. Thacker, MD, director of Cleveland Clinic’s Center for Specialized Women’s Health. “

9. Frictionless Remote Monitoring

The development of a skin-top biosensor that measures insulin and reports the results to both patient and doctor could put an end to the use of needles to test glucose levels.

Needle-free glucose monitoring is only one example of frictionless remote monitoring--other devices in development include a bandage that reads sweat molecules to diagnose pregnancy, hypertension or hydration. Frictionless remote monitoring puts vital data in the hands of both patient and caregiver, effortlessly.

10. Neurovascular Stent Retrievers

For years, the only FDA-approved treatment for stroke has been a clot-busting drug that is not always effective. Neurovascular stent retrievers are inserted into the body through a catheter and threaded through the blood stream, the tiny, wire-caged device seizes the blood clot and removes it. Studies found that stroke victims whose clots were removed via stent retriever had speedier recoveries and improved chances of regaining independence.